Neural Regeneration Research ›› 2013, Vol. 8 ›› Issue (8): 745-753.doi: 10.3969/j.issn.1673-5374.2013.08.009

Previous Articles     Next Articles

The role of local field potential coupling in epileptic synchronization

Jiongxing Wu, Heng Yang, Yufeng Peng, Liangjuan Fang, Wen Zheng, Zhi Song   

  1. Department of Neurology, the Third Xiangya Hospital, Central South University, Changsha 410013, Hunan Province, China
  • Received:2012-10-24 Revised:2013-01-25 Online:2013-03-15 Published:2013-03-15
  • Contact: Zhi Song, M.D., Chief physician, Department of Neurology, the Third Xiangya Hospital, Central South University, Changsha 410013, Hunan Province, China, docsong@126.com.
  • About author:Jiongxing Wu☆, M.D., Attending physician.
  • Supported by:

    This work was supported by grants from the National Natural Science Foundation of China, No. 30971534 and 125 Project of the Third Xiangya Hospital of Central South University, China.

PDF

1046

Abstract:

This review hopes to clearly explain the following viewpoints: (1) Neuronal synchronization underlies brain functioning, and it seems possible that blocking excessive synchronization in an epileptic neural network could reduce or even control seizures. (2) Local field potential coupling is a very common phenomenon during synchronization in networks. Removal of neurons or neuronal networks that are coupled can significantly alter the extracellular field potential. Interventions of coupling mediated by local field potentials could result in desynchronization of epileptic seizures. (3) The synchronized electrical activity generated by neurons is sensitive to changes in the size of the extracellular space, which affects the efficiency of field potential transmission and the threshold of cell excitability. (4) Manipulations of the field potential fluctuations could help block synchronization at seizure onset.

Key words: neural regeneration, reviews, epilepsy, neurons, synchronized discharge, neural network, extracellular space, local potential coupling, field potentials, cell excitation threshold value, grants-supported paper, neuroregeneration