Neural Regeneration Research ›› 2014, Vol. 9 ›› Issue (14): 1341-1346.doi: 10.4103/1673-5374.137585

Previous Articles     Next Articles

Adipose derived stem cells and nerve  regeneration

Alessandro Faroni 1, Richard JP Smith 1, Adam J Reid 1, 2   

  1. 1 Blond McIndoe Laboratories, Institute of Inflammation and Repair, University of Manchester, Manchester, UK
    2 Department of Plastic Surgery & Burns, University Hospital of South Manchester, Manchester, UK
  • Received:2014-06-10 Online:2014-07-25 Published:2014-07-25
  • Contact: Alessandro Faroni, Ph.D., Blond McIndoe Laboratories, Institute of Inflammation and Repair - University of Manchester, 3.107 Stopford Building, Oxford Road, Manchester M13 9PT, UK, alessandro.faroni@manchester.ac.uk.

PDF

1133

Abstract:

Injuries to peripheral nerves are common and cause life-changing problems for patients alongside high social and health care costs for society. Current clinical treatment of peripheral nerve injuries predominantly relies on sacrificing a section of nerve from elsewhere in the body to provide a graft at the injury site. Much work has been done to develop a bioengineered nerve graft, precluding sacrifice of a functional nerve. Stem cells are prime candidates as accelerators of regeneration in these nerve grafts. This review examines the potential of adipose-derived stem cells to improve nerve repair assisted by bioengineered nerve grafts.

Key words: peripheral nerve injury, adipose derived stem cells, nerve guidance tubes, bioengineered nerve graft, axonal regeneration, Schwann cell, cell therapy, nerve repair