Neural Regeneration Research ›› 2016, Vol. 11 ›› Issue (12): 1869-1883.doi: 10.4103/1673-5374.195278

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The dynamics of adult neurogenesis in human hippocampus

Amadi O. Ihunwo*, Lackson H. Tembo, Charles Dzamalala   

  1. School of Anatomical Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
  • Received:2016-11-18 Online:2016-12-31 Published:2016-12-31
  • Contact: Amadi O. Ihunwo, Ph.D., Amadi.Ihunwo@wits.ac.za.
  • Supported by:
    This work was supported by the Consortium for Advanced Research Training in Africa (CARTA). CARTA is jointly led by the African Population and Health Research Center (APHRC) and the University of the Witwatersrand and funded by the Wellcome Trust (UK) (Grant No. 087547/Z/08/Z), the Department for International Development (DfID) under the Development Partnerships in Higher Education (DelPHE), the Carnegie Corporation of New York (Grant No. B 8606), the Ford Foundation (Grant No. 11000399), Google.Org (Grant No. 191994), Sida (Grant No. 54100029), MacArthur Foundation (Grant No. 10-95915-000-INP) and British Council.

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Abstract: The phenomenon of adult neurogenesis is now an accepted occurrence in mammals and also in humans. At least two discrete places house stem cells for generation of neurons in adult brain. Tese are olfactory system and the hippocampus. In animals, newly generated neurons have been directly or indirectly demonstrated to generate a signifcant amount of new neurons to have a functional role. However, the data in humans on the extent of this process is still scanty and such as difcult to comprehend its functional role in humans. Tis paper explores the available data on as extent of adult hippocampal neurogenesis in humans and makes comparison to animal data.

Key words: adult neurogenesis, neuron, neuronal stem cell, proliferation, differentiation, neuronal turn-over, hippocampus, human neurogenesis