This work is funded by FONDAP program 15150012 (to CH and FAC), Millennium Institute, No. P09-015-F, the Frick Foundation 20014-15, ALS Therapy Alliance 2014-F-059, Muscular Dystrophy Association 382453, CONICYT-USA 2013-0003, Michael J Fox Foundation for Parkinson′s Research – Target Validation grant No 9277, COPEC- UC Foundation 2013.R.40, Ecos-Conicyt C13S02, FONDECYT No. 1140549, Office of Naval Research-Global (ONR-G) N62909-16-1-2003 and ALSRP Therapeutic Idea Award AL150111 (to CH), Millennium Nucleus-P-07-011-F, FONDECYT, No. 1110987 (to FAC), and PhD fellow supported by CONICYT, No. 21130843 (to MO).