I thank Trace Christensen for help with Figures and together with Drs. Sergey Trushin and Jeffrey L. Salisbury for comments on the paper. My apologies to all authors whose work could not be cited here due to page limitations. This work was partially supported by grants from NIEHS R01ES020715, ADDF 291204, BrightFocus A2011084, GHR Foundation, and NCATS UL1 TR000135.