Neural Regeneration Research ›› 2018, Vol. 13 ›› Issue (4): 635-636.doi: 10.4103/1673-5374.230283

Previous Articles     Next Articles

Epigenetic interventions for brain rejuvenation: anchoring age-related transposons

Adonis Sfera1, Lisa Fayard2, Carolina Osorio2, Amy Price3   

  1. 1 Department of Psychiatry, Patton State Hospital, Patton, CA, USA;
    2 Department of Psychiatry, Loma Linda University, Loma Linda, CA, USA;
    3 Evidence-Based Medicine, University of Oxford, Oxford, UK
  • Received:2018-03-12 Online:2018-04-15 Published:2018-04-15
  • Contact: Adonis Sfera, M.D., dr.sfera@gmail.com

PDF

240

Abstract:

Highlights:
1. Iron and homocysteine accumulation in aging neurons alter genomic methylation.
2. The altered methylome reactivates neuronal cell cycle, enabling transposable element mobilization.
3. miR29/p53 axis restores age-related methylation shifts, reactivating neuronal plasticity.
4. Augmentation of miR-29/p53 axis may preempt neurodegenerative disorders.