Neural Regeneration Research ›› 2019, Vol. 14 ›› Issue (1): 20-23.doi: doi:10.4103/1673-5374.243695

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Memory consolidation during sleep and adult hippocampal neurogenesis

Iyo Koyanagi1, Katherine G. Akers2, Pablo Vergara1, Sakthivel Srinivasan1, Takeshi Sakurai1, Masanori Sakaguchi1   

  1. 1 International Institute for Integrative Sleep Medicine, University of Tsukuba, Tsukuba, Japan;
    2 Shiffman Medical Library, Wayne State University, Detroit, MI, USA
  • Online:2019-01-15 Published:2019-01-15
  • Contact: Masanori Sakaguchi, MD, PhD, masanori.sakaguchi@gmail.com
  • Supported by:

    This work was partially supported by the MEXT World Premier International Research Center Initiative, CREST JST, MEXT KAKENHI for Scientific Research on Innovative Areas “Microendophenotype” (25116530) and “Memory Dynamism” (26115502), JSPS KAKENHI Grants (16K18359, 15F15408), Research Foundation for Opto-Science and Technology, Kato Memorial Bioscience Foundation, Japan Foundation for Applied Enzymology, Uehara Memorial Foundation, 2016 Inamori Research Grants Program, Ichiro Kanehara Foun-dation for the Promotion of Medical Sciences and Medical Care, Life Science Foundation of Japan, Kowa Life Science Foundation Research Grant, GSK Japan Research Grant, and KANAE Foundation for the Promotion of Medical Science,

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Abstract:

In anticipation of the massive burden of neurodegenerative disease within super-aged societies, great efforts have been made to utilize neural stem and progenitor cells for regenerative medicine. The capacity of intrinsic neural stem and progenitor cells to regenerate damaged brain tissue remains unclear, due in part to the lack of knowledge about how these newly born neurons integrate into functional circuitry. As sizable integration of adult-born neurons naturally occurs in the dentate gyrus region of the hippocampus, clarifying the mechanisms of this process could provide insights for applying neural stem and progenitor cells in clinical settings. There is convincing evidence of functional correlations between adult-born neurons and memory consolidation and sleep; therefore, we describe some new advances that were left untouched in our recent review.