Neural Regeneration Research ›› 2019, Vol. 14 ›› Issue (2): 262-264.doi: 10.4103/1673-5374.244789

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Lessons from tenascin-C knockout mice and potential clinical application to subarachnoid hemorrhage

Masato Shiba, Hidenori Suzuki   

  1. Department of Neurosurgery, Mie University Graduate School of Medicine, Tsu, Japan
  • Online:2019-02-15 Published:2019-02-15
  • Contact: Hidenori Suzuki, MD, PhD, suzuki02@clin.medic.mie-u.ac.jp.
  • Supported by:

    This work was funded by a grant-in-aid for Scientific Research from Japan Society for the Promotion of Science, No.17K10825 (to HS) and 17K16640 (to MS).

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Abstract:

Subarachnoid hemorrhage by a ruptured cerebral aneurysm remains the most devastating cerebrovascular disorders with high morbidity and mortality, which are mainly caused by early brain injury and delayed cerebral ischemia. Despite many experimental and clinical research efforts, the mechanisms of early brain injury as well as delayed cerebral ischemia remain unclarified. However, recent works have suggested that tenascin-C, which is a special type of secreted extracellular matrix proteins, is promising as a novel therapeutic target against post-subarachnoid hemorrhage early brain injury and delayed cerebral ischemia.