Neural Regeneration Research ›› 2020, Vol. 15 ›› Issue (10): 1840-1841.doi: 10.4103/1673-5374.280309

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The Janus face of N-terminal lysines in α-synuclein

Ana Belén Uceda, Laura Mariño, Miquel Adrover   

  1. Institut Universitari d’Investigació en Ciències de la Salut (IUNICS), Institut d’Investigació Sanitària Illes Balears (IdISBa), Departament de Química, Universitat de les Illes Balears, Palma de Mallorca, Spain
  • Online:2020-10-15 Published:2020-08-06
  • Contact: Miquel Adrover, PhD, miquel.adrover@uib.es.
  • Supported by:
    This work was supported by the Spanish Government in the framework of Project CTQ2014-55835-R. LM thanks MINECO for award of FPU PhD Grant FPU14/01131.

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Abstract: Parkinson’s disease (PD) is the second most prevalent progressive neurodegenerative disorder after Alzheimer’s disease. PD usually starts with a tremor in the extremities (usually in the hands) and gradually evolves with other symptoms such as bradykinesia, muscle stiffness, impaired posture, loss of automatic movements or speech changes. These symptoms worsen as the condition progresses and eventually lead to death.