Abstract: Numbers of visually-impaired adults are rising rapidly around the globe. Neuronal transplantation therapies show great promise to restore vision, but have been severely impeded by poor synaptic positioning within retinal host. This perspectives article highlights our group’s abilities to remarkably direct the migration of transplantable cells by applying electro-chemical fields within retina-customized microtechnology. Integration of our in vitro results with current ex vivo and in vivo studies has the potential to transformatively impact outcomes of cell replacement therapy.