Abstract: Inflammatory processes play a critical role in neurodegenerative diseases, such as Parkinson’s disease (PD). Thus, neuroinflammation is involved in the progression and development of these diseases, becoming an important pathological hallmark. Microglial cells, the “macrophages” from central nervous system, are the initiating cells of the innate immune response against different stimuli in the brain. Even though they have a major role in brain homeostasis maintenance, their uncontrolled activation results in the secretion of pro-inflammatory cytokines and production of reactive oxygen species (ROS), leading to neuronal damage and death. Microglial cells present different phenotypes, ranging from pro-inflammatory/neurotoxic to anti-inflammatory/neuroprotective phenotype, depending on the stimulants involved (Shen et al., 2018). For this reason, novel therapeutic strategies are being addressed in order to shift the microglia polarization. Among them it is worth mentioning the search for dietary bioactive compounds, which may prevent or delay the progression of neuroinflammation and, in consequence, reduce the neuronal damage caused by microglia overactivation.