Abstract: Regeneration of long axons after the spinal cord injury (SCI) will benefit patients with extensive traumatic damage to the white matter pathways who experience intolerable, permanent, neurologic deficits even after neuroprotective treatment with anti-inflammatory agents (Kwiecien, 2021a). This short paper attempts to synthetize pathologic mechanisms or barriers involved in inhibition of axonal regeneration in the SCI and provides suggestions of therapeutic interventions enabling this regeneration in animal models.