Abstract: In a symbiotic and mutualistic manner, the gut microbiota strongly influences many vital aspects of host physiology, biology, repair, and regeneration. The role of microbiota in many areas of regenerative medicine is just beginning to emerge, but it is under-recognized because of its complexity. As we remove the barriers that impede our understanding of this complex entity, we will uncover some of the most vital facets of our microbiome that make us who we are, its intrinsic connection with not only our wellbeing, but also with regeneration within. This will subsequently define its utility in regenerative medicine.