Neural Regeneration Research ›› 2023, Vol. 18 ›› Issue (12): 2638-2644.doi: 10.4103/1673-5374.373678

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Molecular chaperones in stroke-induced immunosuppression

Haoduo Qiao1, 2, 3, 4, Qing Xu1, 2, 3, 4, Yunfei Xu1, 2, 3, 4, Yao Zhao1, 2, 3, 4, Nina He1, 2, 3, 4, Jie Tang5, Jie Zhao1, 2, 3, 4, *, Ying Liu1, 2, 3, 4, *   

  1. 1Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan Province, China; 2Department of Pathophysiology, Xiangya School of Medicine, Central South University, Changsha, Hunan Province, China; 3Sepsis Translational Medicine Key Laboratory of Hunan Province, Changsha, Hunan Province, China; 4National Medicine Functional Experimental Teaching Center, Changsha, Hunan Province, China; 5Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan Province, China
  • Online:2023-12-15 Published:2023-06-14
  • Contact: Ying Liu, PhD, liu1977ying@csu.edu.cn; Jie Zhao, PhD, steelzj@csu.edu.cn.
  • Supported by:
    This work was supported by the National Natural Science Foundation of China, Nos. 82172147 (to YL), 81571880 (to YL), 81373147 (to YL), 30901555 (to JZ), 30972870 (to YL) and the Natural Science Foundation of Hunan Province, Nos. 2021JJ30900, 2016JJ2157 (both to YL). 

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Abstract: Stroke-induced immunosuppression is a process that leads to peripheral suppression of the immune system after a stroke and belongs to the central nervous system injury-induced immunosuppressive syndrome. Stroke-induced immunosuppression leads to increased susceptibility to post-stroke infections, such as urinary tract infections and stroke-associated pneumonia, worsening prognosis. Molecular chaperones are a large class of proteins that are able to maintain proteostasis by directing the folding of nascent polypeptide chains, refolding misfolded proteins, and targeting misfolded proteins for degradation. Various molecular chaperones have been shown to play roles in stroke-induced immunosuppression by modulating the activity of other molecular chaperones, cochaperones, and their associated pathways. This review summarizes the role of molecular chaperones in stroke-induced immunosuppression and discusses new approaches to restore host immune defense after stroke.

Key words: Hsp70, Hsp72, Hsp90, HspB5, hypothalamic-pituitary-adrenal axis, molecular chaperones, neuroprotection, stroke, stroke-induced immunosuppression, sympathetic nervous system