Neural Regeneration Research ›› 2023, Vol. 18 ›› Issue (12): 2671-2672.doi: 10.4103/1673-5374.373685

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Historic recurrences in medicinal chemistry: nature-inspired structures as a new opportunity for novel multi-target anti-Alzheimer’s drugs

Luca Piemontese*   

  1. Università degli Studi di Bari Aldo Moro, Dipartimento di Farmacia-Scienze del Farmaco, via E. Orabona, Bari, Italy
  • Online:2023-12-15 Published:2023-06-14
  • Contact: Luca Piemontese, PhD, luca.piemontese@uniba.it.

Abstract: Alzheimer’s disease (AD) is an alarming non-communicable, multi-factorial, and non-treatable disease. Its underlying neurodegenerative events have not yet been fully explained and its early diagnosis is very difficult. The appearance of the disease is associated with clinical features such as the degeneration of several cholinergic nuclei of the brain, causing lower levels of the neurotransmitter acetylcholine and the formation of protein aggregates in the inter-synaptic space (amyloid plaques) or inside the cells (neurofibrillary tangles, Brunetti et al., 2020).