Neural Regeneration Research ›› 2023, Vol. 18 ›› Issue (3): 469-473.doi: 10.4103/1673-5374.350188

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Role of the histone methyltransferases Ezh2 and Suv4-20h1/Suv4-20h2 in neurogenesis

Christopher T. Rhodes1, *, Chin-Hsing Annie Lin2, 3, *   

  1. 1Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, MD, USA; 2Department of Integrative Biology, University of Texas at San Antonio, San Antonio, TX, USA; 3University of Texas at San Antonio Neurosciences Institute, San Antonio, TX, USA
  • Online:2023-03-15 Published:2022-08-25
  • Contact: Christopher T. Rhodes, PhD, christopher.rhodes@nih.gov or chrisrhodes031@gmail.com; Chin-Hsing Annie Lin, PhD, annie.lin@utsa.edu.

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Abstract: Mechanisms regulating neurogenesis involve broad and complex processes that represent intriguing therapeutic targets in the field of regenerative medicine. One influential factor guiding neural stem cell proliferation and cellular differentiation during neurogenesis are epigenetic mechanisms. We present an overview of epigenetic mechanisms including chromatin structure and histone modifications; and discuss novel roles of two histone modifiers, Ezh2 and Suv4-20h1/Suv4-20h2 (collectively referred to as Suv4-20h), in neurodevelopment and neurogenesis. This review will focus on broadly reviewing epigenetic regulatory components, the roles of epigenetic components during neurogenesis, and potential applications in regenerative medicine.

Key words: adult neurogenesis, epigenetic, Ezh2, histone co-regulation, histone modification, neurodevelopment, neurogenesis, regenerative medicine, Suv4-20h