Neural Regeneration Research ›› 2024, Vol. 19 ›› Issue (3): 477-478.doi: 10.4103/1673-5374.380889

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Iron regulatory protein 1: the deadly switch of ferroptosis

Daniel A. Bórquez, Pamela J. Urrutia*   

  1. Center for Biomedical Research, Faculty of Medicine, Universidad Diego Portales, Santiago, Chile (Bórquez DA)
    Institute of Nutrition & Food Technology (INTA), Universidad de Chile, Santiago, Chile (Urrutia PJ)
    Geroscience Center for Brain Health and Metabolism, Santiago, Chile (Urrutia PJ)
  • Online:2024-03-15 Published:2023-09-01
  • Contact: Pamela J. Urrutia, PhD, pamela.urrutia@uchile.cl.
  • Supported by:
    This work was supported by FONDECYT Initiation in Research, grant number 11201141, awarded to PJU.

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Abstract: Ferroptosis, an iron-dependent cell death: Ferroptosis is a type of regulated necrosis, characterized by redox-active iron accumulation and increased free radical production derived by Fenton chemistry, that triggers oxidation of polyunsaturated fatty acids in phospholipids, loss of cellular membranes integrity, and leakage of intracellular contents.