Neural Regeneration Research ›› 2024, Vol. 19 ›› Issue (3): 598-605.doi: 10.4103/1673-5374.380872

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Cell metabolism pathways involved in the pathophysiological changes of diabetic peripheral neuropathy

Yaowei Lv1, 2, #, Xiangyun Yao1, 2, 3, #, Xiao Li1, 2, 4, Yuanming Ouyang1, 2, 3, Cunyi Fan1, 2, 3, Yun Qian1, 2, 3, *   

  1. 1Department of Orthopedics, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China; 2Shanghai Engineering Research Center for Orthopaedic Material Innovation and Tissue Regeneration, Shanghai, China; 3Youth Science and Technology Innovation Studio of Shanghai Jiao Tong University School of Medicine, Shanghai, China; 4College of Fisheries and Life Science, Shanghai Ocean University, Shanghai, China
  • Online:2024-03-15 Published:2023-09-02
  • Contact: Yun Qian, MD, lollipopcloudland@foxmail.com.
  • Supported by:
    This work was supported by the Projects of the National Key R&D Program of China, Nos. 2021YFC2400803 (to YO), 2021YFC2400801 (to YQ); the National Natural Science Foundation of China, Nos. 82002290 (to YQ), 82072452 (to YO), 82272475 (to YO); the Young Elite Scientist Sponsorship Program by Cast, No. YESS20200153 (to YQ); the Sino-German Mobility Programme, No. M-0699 (to YQ); the Excellent Youth Cultivation Program of Shanghai Sixth People’s Hospital, No. ynyq202201 (to YQ); the Shanghai Sailing Program, No. 20YF1436000 (to YQ); the Medical Engineering Co-Project of University of Shanghai for Science and Technology, 10-22-310-520 (to YO); and a grant from Shanghai Municipal Health Commission, No. 202040399 (to YO).

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Abstract: Diabetic peripheral neuropathy is a common complication of diabetes mellitus. Elucidating the pathophysiological metabolic mechanism impels the generation of ideal therapies. However, existing limited treatments for diabetic peripheral neuropathy expose the urgent need for cell metabolism research. Given the lack of comprehensive understanding of energy metabolism changes and related signaling pathways in diabetic peripheral neuropathy, it is essential to explore energy changes and metabolic changes in diabetic peripheral neuropathy to develop suitable treatment methods. This review summarizes the pathophysiological mechanism of diabetic peripheral neuropathy from the perspective of cellular metabolism and the specific interventions for different metabolic pathways to develop effective treatment methods. Various metabolic mechanisms (e.g., polyol, hexosamine, protein kinase C pathway) are associated with diabetic peripheral neuropathy, and researchers are looking for more effective treatments through these pathways.

Key words: cell metabolism, diabetic peripheral neuropathy, peripheral nerve injury, protein kinase C pathway, reactive oxygen species