Abstract: Neural stem cells (NSCs) are the source of all neurons and glial cells (astrocytes and oligodendrocytes) in the central nervous system. The adult mammalian brain retains NSCs in the subgranular zone of the dentate gyrus in the hippocampus and ventricular subventricular zone lining the lateral ventricle (Olpe and Jessberger, 2022). Adult NSCs in rodents are preserved throughout life and continuously produce new neurons that integrate into the pre-existing neuronal network. However, whether adult neurogenesis occurs in humans, especially in the hippocampus, remains yet to be proven (Olpe and Jessberger, 2022). Adult neurogenesis in the hippocampus contributes to hippocampus-dependent cognitive function (Gonçalves et al., 2016). Disruption of this neurogenesis is known to be associated with several brain disorders, such as age-dependent cognitive decline, major depressive disorders, and medial-temporal lobe epilepsy. Thus, elucidating the mechanisms underlying the regulation of NSC behavior and neurogenesis is important for developing therapeutic strategies to treat diseases related to impaired adult neurogenesis.