Neural Regeneration Research ›› 2024, Vol. 19 ›› Issue (5): 937-938.doi: 10.4103/1673-5374.385292

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Beyond functional MRI signals: molecular and cellular modifiers of the functional connectome and cognition

Lorenzo Pini*, Alessandro Salvalaggio, Maurizio Corbetta   

  1. Padova Neuroscience Center, University of Padova, Italy (Pini L, Salvalaggio A, Corbetta M)
    Veneto Institute of Molecular Medicine, VIMM, Padova, Italy (Pini L, Corbetta M)
    Department of Neuroscience, University of Padova, Italy (Salvalaggio A, Corbetta M)
  • Online:2024-05-15 Published:2023-10-31
  • Contact: Lorenzo Pini, PhD, pini.lorenzo2@gmail.com.

Abstract: Our brain is constantly active. Even at rest, the brain carries out essential functions such as maintenance of resting potentials, subthreshold synaptic activity, and spiking activity related to information processing. This resting activity can be assessed with several in vivo tools, such as resting-state functional magnetic resonance imaging. This technique measures subtle changes in blood flow, volume, and oxygenation that occur over time. Although vascular in nature, resting-state functional magnetic resonance imaging is considered a reliable proxy of neural activity and several studies have shown that the brain is functionally divided into interacting neural networks called the “functional connectome”.