Neural Regeneration Research ›› 2024, Vol. 19 ›› Issue (7): 1425-1426.doi: 10.4103/1673-5374.387991

Previous Articles     Next Articles

NLRP3 inflammasome plays a vital role in the pathogenesis of age-related diseases in the eye and brain

Jack Jonathan Maran, Odunayo Omolola Mugisho*#br#   

  1. Buchanan Ocular Therapeutics Unit, Department of Ophthalmology, New Zealand National Eye Centre, University of Auckland, Auckland, New Zealand
  • Online:2024-07-15 Published:2023-11-28
  • Contact: Odunayo Omolola Mugisho, PhD, lola.mugisho@auckland.ac.nz.
  • Supported by:
    This work was supported by a Neurological Foundation First Postdoctoral Research Fellowship (2001 FFE) and an Auckland Medical Research Foundation Grant (1121013) (to OOM).

PDF

26

Abstract: Key points: With aging, there is increased nucleotide-binding oligomerization domain-(NOD-) like receptor (NLR) protein-3 (NLRP3) activation in neural and ocular tissues. Activation of the NLRP3 inflammasome appears to be a common denominator in the pathogenesis of age-related diseases of the eye and brain. Pharmacological inhibition of the NLRP3 inflammasome may be a potent therapy for preventing the development and progression of age-related eye and brain diseases.