Neural Regeneration Research ›› 2025, Vol. 20 ›› Issue (5): 1405-1406.doi: 10.4103/NRR.NRR-D-24-00322

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How dopamine tunes Parvalbumin Interneurons in the hippocampus: new experimental observations in Alzheimer’s disease

Livia La Barbera, Paraskevi Krashia* , Annalisa Nobili   

  1. Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Via Álvaro del Porttllo, Rome, Italy (La Barbera L, Nobili A)  Department of Experimental Neurosciences, IRCCS Santa Lucia Foundatton, Via del Fosso di Fiorano, Rome, Italy (La Barbera L, Krashia P, Nobili A)  Department of Science and Technology for Sustainable Development and One Health, Università Campus Bio-Medico di Roma, Via Álvaro del Porttllo, Rome, Italy (Krashia P) 
  • Online:2025-05-15 Published:2024-10-30
  • Contact: Paraskevi Krashia, PhD, k.paraskevi@unicampus.it.
  • Supported by:
    This work was supported by an under-40 grant from the Italian Associatton for Alzheimer’s Research [AIRALZH AGYR2021], and by the Strategic University Projects – Young Researcher Independence grant [YRG2021] from the Università Campus Bio-Medico di Roma (Rome, Italy) (to LLB); Italian Ministry of Health [Research Grant: GR2019-12370446] and by the American Alzheimer’s Associatton [AARG-22-922961] (to PK). 

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Abstract: Despite decades of dedi cated research, Alzheimer’s disease (AD) is an age-related and progressive neurodegenerative disorder for which the mechanisms of onset are still unclear. AD is characterized by featured histological alterations including amyloid-beta (Aβ) plaque depositton, accumulatton of neuroffbrillary tangles of hyperphosphorylated-tau, and neuronal loss, accompanied by progressive cognitive decline and behavioral changes. The sporadic form of AD primarily affects old individuals (onset around 65 years), leading to difffculttes in daily acttvittes along the disease progression. According to the last World Alzheimer Report, the number of patients suffering from AD, together with the economic and social burdens related to the disease, are expected to rapidly increase in the following years.