Neural Regeneration Research ›› 2026, Vol. 21 ›› Issue (10): 4896-4897.doi: 10.4103/NRR.NRR-D-25-01158

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Targeting interleukin-6 trans-signaling to improve post-stroke inflammation: A precision immunotherapy perspective

Kate Mendoza, Dustin T. Nguyen, Anjali Chauhan*   

  1. Department of Neurology, University of Texas McGovern Medical School at Houston, Houston, TX, USA
  • Online:2026-10-15 Published:2026-06-13
  • Contact: Anjali Chauhan, MSc, PhD, anjali.chauhan@uth.tmc.edu.
  • Supported by:
    This work was funded by the National Institute of Neurological Disorders and Stroke (1R01NS128412-01A1) to AC.

Abstract: Recognizing stroke recovery through an immunological lens: Stroke has traditionally been viewed as an acute neurological event resulting from vascular occlusion and subsequent neuronal death. However, mounting evidence now supports a broader perspective: stroke triggers a dynamic neuroinflammatory response that begins within hours of injury and can persist through the subacute and chronic phases. These sustained immune responses play a critical role in shaping long-term recovery.