Abstract: With the industrialization of agriculture and the advancement of medical care, human life expectancy has increased considerably and continues to rise steadily. This results in novel and unprecedented challenges, namely obesity and neurodegeneration. Understanding the intimate link between these two pathologies will enhance our understanding of brain-body crosstalk to develop effective treatments to halt the rising rates of obesity and neurological disorders. Obesity increases the risk of cognitive decline and neurological disorders; however, it remains unclear the exact mechanisms of obesity-induced neurodegeneration. This perspective proposes iron as a nexus between obesity and neurological disorders through the reshaping of the neuro-glialvascular landscape.