Neural Regeneration Research ›› 2026, Vol. 21 ›› Issue (5): 2003-2005.doi: 10.4103/NRR.NRR-D-24-01481

Previous Articles     Next Articles

Secretase inhibition in Alzheimer’s disease therapeutics reveals functional roles of amyloid-beta42

Timothy Daly* , Bruno P. Imbimbo   

  1. UMR 1219 (Bordeaux Population Health) University of Bordeaux & INSERM, Bordeaux, France (Daly T) CNS UMR 5164 (ImmunoConcept), University of Bordeaux, Bordeaux, France (Daly T) Bioethics Program, FLACSO Argentina, Tucumán, Buenos Aires, Argentina (Daly T) Research & Development, Chiesi Farmaceutici, Parma, Italy (Imbimbo BP)
  • Online:2026-05-15 Published:2025-08-22
  • Contact: Timothy Daly, PhD, timothy.daly@u-bordeaux.fr.
  • Supported by:
    Dr. Timothy Daly has no financial relationships or conflicts of interest to declare. Dr. Bruno P. Imbimbo is an employee at Chiesi Farmaceutici. He is listed as an inventor in a number of Chiesi Farmaceutici’s patents of anti-Alzheimer drugs. No conflicts of interest exist between Chiesi Farmaceutici and publication of this article. The words of Sir Colin Blakemore were paraphrased from a 2014 public lecture he gave at the “Brain Matters” event at the University of Nottingham, attended by Timothy Daly (https://www.nottingham.ac.uk/research/groups/ neuroscience/brainmatters/an-evening-with/tickets. aspx#book)

Abstract: In the words of the late Sir Colin Blakemore, neurologists have historically sought to infer brain functions in a manner akin to taking a hammer to a computer— analyzing localized anatomical lesions caused by trauma, tumors, or strokes, noting deficits, and inferring what functions certain brain regions may be responsible for. This approach exemplifies a deletion heuristic, where the absence of a specific function reveals insights about the underlying structures or mechanisms responsible for it. By observing what is lost when a particular brain region is damaged, throughout the history of the field, neurologists have pieced together the intricate relationship between anatomy and function.