Neural Regeneration Research ›› 2026, Vol. 21 ›› Issue (7): 2818-2819.doi: 10.4103/NRR.NRR-D-25-00510

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Gamma entrainment as a functional target in deep brain stimulation

Bandy Chen*   

  1. Department of Medicine, UC San Diego School of Medicine, La Jolla, CA, USA
  • Online:2026-07-15 Published:2025-10-20
  • Contact: Bandy Chen, bac008@health.ucsd.edu.

Abstract: Deep brain stimulation (DBS) is a neuromodulation tool that involves the delivery of electrical impulses to specific brain regions through implanted electrodes. The principle behind DBS is to modulate dysfunctional neural circuits without the need for permanent structural alterations to the brain. Initially developed as a treatment for movement disorders such as Parkinson’s disease (PD), DBS has expanded to encompass various neurological and psychiatric disorders. Until recently, DBS uses high-frequency electrical pulses to disrupt abnormal patterns of brain activity. Recent advances in neuroscience are shifting toward precision-based rhythm restoration with the goal of reinstating normal oscillatory patterns. Entrainment of brain activity within the gamma range (30–100 Hz), particularly around 40 Hz, has demonstrated potential in improving neurological disorders such as Alzheimer’s disease (AD) and PD (Deng et al., 2024). This represents a shift in the goal of DBS from silencing neural circuits to restoring physiological brain rhythms.