Abstract: Amyloidosis is a group of diseases caused by the abnormal accumulation of amyloid fibrils (misfolded protein aggregates) in various human tissues. These amyloid deposits can interfere with normal organ function and lead to severe health issues. Amyloid plaque formation in the brain is linked to neurodegenerative diseases, including Tau and Aβ plaques in Alzheimer ’s disease, α-synuclein plaques in Parkinson’s disease, and huntingtin plaques in Huntington’s disease. Although this condition is typically associated with aging, certain mutations in amyloid-forming proteins can trigger early-onset amyloidosis (Hatami et al., 2017). Given its progressive and lifethreatening nature