Neural Regeneration Research ›› 2026, Vol. 21 ›› Issue (8): 3527-3528.doi: 10.4103/NRR.NRR-D-25-00516

Previous Articles     Next Articles

Role of prion protein in mediating the synaptotoxic effects of tau oligomers: Implications for Alzheimer's disease and related tauopathies

Roberto Chiesa*, Luana Fioriti, Gianluigi Forloni, Claudia Balducci*   

  1. Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy
  • Online:2026-08-18 Published:2026-04-25
  • Contact: Roberto Chiesa, PhD, roberto.chiesa@marionegri.it; Claudia Balducci, PhD, claudia.balducci@marionegri.it.
  • Supported by:
    This study was supported by the Italian Ministry of Health grant RF‐2021‐12372337 (to GF and CB).

PDF

5

Abstract: Alzheimer’s disease (AD) and other tauopathies are characterized by the accumulation of misfolded tau protein, which forms toxic oligomers that contribute to synaptic dysfunction and neuronal loss. Here, we briefly discuss recent findings indicating that the cellular prion protein (PrPC) plays a critical role in mediating the synaptotoxic effects of tau oligomers (TauOs), offering new insights into disease pathogenesis and potential therapeutic strategies.