Neural Regeneration Research ›› 2026, Vol. 21 ›› Issue (8): 3565-3566.doi: 10.4103/NRR.NRR-D-25-01176

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Cannabidiol extending beyond neuroprotection toward neuronal repair: A potential regenerative modulator

María Salud García-Gutiérrez, Jorge Manzanares*   

  1. Instituto de Neurociencias, Universidad Miguel Hernández-CSIC, San Juan de Alicante, Alicante, Spain (García-Gutiérrez MS, Manzanares J)
    Red de Investigación en Atención Primaria de Adicciones, Instituto de Salud Carlos III, MICINN and FEDER, Madrid, Spain (García-Gutiérrez MS, Manzanares J)
    Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), Alicante, Spain (García-Gutiérrez MS, Manzanares J)
  • Online:2026-08-18 Published:2026-04-25
  • Contact: Jorge Manzanares, PhD, jmanzanares@umh.es.
  • Supported by:
    Innovation, grant number RD21/0009/0008 and RD24/0003/0002, and Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL) to JM. The Instituto de Neurociencias is a “Centre of Excellence Severo Ochoa” (CEX2021-001165-S).

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Abstract: Cannabidiol (CBD), the second most significant phytocannabinoid in the plant Cannabis sativa, which lacks potential as a drug of abuse (Viudez-Martinez et al., 2019), has gained widespread attention due to its anti-inflammatory, antioxidant, and antidepressant properties ( Garcia-Gutierrez et al., 2020). Additionally, CBD exhibits neuroprotective properties, preserving neuronal viability and function by preventing or limiting cellular damage. Our team has demonstrated that CBD produces rapid antidepressant-like effects in a murine model of chronic mild stress, restoring hippocampal expression of brain-derived neurotrophic factor (BDNF), serotonin 1A (5-HT1A), and peroxisome proliferator-activated receptor delta (PPARδ), and surpassing the effects of the conventional selective serotonin reuptake inhibitor sertraline. Similarly, CBD promotes hippocampal neurogenesis and enhances synaptic plasticity (Garcia-Gutierrez et al., 2023). Besides, CBD restores hippocampal neurodegeneration in a mouse model of fetal alcohol spectrum disorder (Gasparyan et al., 2023).