Abstract:

Evidence suggests that autophagy may be a new therapeutic target for stroke, but whether activation of autophagy increases or decreases the rate of neuronal death is still under debate. This review summarizes the potential role and possible signaling pathway of autophagy in neuronal survival after cerebral ischemia and proposes that autophagy has dual effects.

Key words: nerve regeneration, autophagy, lysosome, autophagosome, neuron, cerebral ischemia, signaling pathway, apoptosis, necrosis, survival, NSFC grant, neural regeneration