Neural Regeneration Research ›› 2014, Vol. 9 ›› Issue (14): 1402-1408.doi: 10.4103/1673-5374.137596

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Cholecystokinin octapeptide antagonizes apoptosis in human retinal pigment epithelial cells

Yuan Liu 1, Yueling Zhang 1, Zhaohui Gu 1, Lina Hao 2, Juan Du 1, Qian Yang 1, Suping Li 1, Liying Wang 1, Shilei Gong 3   

  1. 1 Department of Ophthalmology, First Central Hospital of Baoding, Baoding, Hebei Province, China
    2 Department of Ophthalmology, Hebei Province People’s Hospital, Shijiazhuang, Hebei Province, China
    3 Department of Endoscope Room, First Central Hospital of Baoding, Baoding, Hebei Province, China
  • Received:2014-05-24 Online:2014-07-25 Published:2014-07-25
  • Contact: Lina Hao, M.D., Department of Ophthalmology, Hebei Province People’s Hospital, Shijiazhuang, Hebei Province, China, 75765892@qq.com.

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Abstract:

Although cholecystokinin octapeptide-8 is important for neurological function, its neuroprotective properties remain unclear. We speculated that cholecystokinin octapeptide-8 can protect human retinal pigment epithelial cells against oxidative injury. In this study, retinal pigment epithelial cells were treated with peroxynitrite to induce oxidative stress. Peroxynitrite triggered apoptosis in these cells, and increased the expression of Fas-associated death domain, Bax, caspa-
se-8 and Bcl-2. These changes were suppressed by treatment with cholecystokinin octapeptide-8. These results suggest that cholecystokinin octapeptide-8 can protect human retinal pigment epithelial cells against apoptosis induced by peroxynitrite.

Key words: nerve regeneration, retinal pigment epithelial cells, peroxynitrite, cholecystokinin octapeptide, apoptosis, Fas-associated death domain, Bax, Caspase-8, Bcl-2, neural regeneration