Neural Regeneration Research ›› 2012, Vol. 7 ›› Issue (27): 2136-2143.

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Neurochemical mechanism of the gastrointestinal interdigestive migrating motor complex in rats with acute inflammatory stomach ache

Xiaoli Xu1, Qin Li2, Lv Zhou3, Liqiang Ru2   

  1. 1 Department of Anatomy, School of Medicine, Jianghan University, Wuhan 430056, Hubei Province, China
    2 Department of Neurobiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
    3 Department of Physiology, Institute of Basic Medical Science, Chinese Academy of Medical Science, Beijing 100005, China
  • Received:2012-05-11 Revised:2012-07-10 Online:2012-09-25 Published:2012-09-25
  • Contact: Lv Zhou, Doctoral supervisor, Professor, Department of Physiology, Institute of Basic Medical Science, Chinese Academy of Medical Science, Beijing 100005, China Luzhou_88@yahoo.com.cn
  • About author:Xiaoli Xu, Associate professor, Department of Anatomy, School of Medicine, Jianghan University, Wuhan 430056, Hubei Province, China

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Abstract:

The normal gastrointestinal interdigestive migrating motor complex cycle was interrupted, and paroxysmal contraction appeared after formaldehyde-induced stomach ache. Activities of nitric oxide synthase, acetylcholinesterase and vasoactive intestinal peptide neurons were significantly reduced, whereas activities of calcitonin gene-related peptide neurons were significantly increased in the pyloric sphincter muscular layer, myenteric nerve plexus and submucous nerve plexus. Electroacupuncture at Zusanli (ST36) suppressed paroxysmal contraction in rats with formaldehyde-induced stomach ache, and neurons in the enteric nervous system were normal. These results indicated that nitrergic neurons, cholinergic neurons, vasoactive intestinal peptide neurons and calcitonin gene-related peptide neurons in the enteric nervous system may be involved in changes to the gastrointestinal interdigestive migrating motor complex following stomach ache, and that electroacupuncture can regulate this process.

Key words: pyloric sphincter, inflammatory pain, interdigestive migrating motor complex, enteric nervous system, electroacupuncture, neural regeneration