Neural Regeneration Research ›› 2020, Vol. 15 ›› Issue (7): 1199-1207.doi: 10.4103/1673-5374.272567

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Adrenomedullin: an important participant in neurological diseases

  

  1. College of Life Sciences, Laboratory of Neuroendocrinology, Provincial Key Laboratory of Developmental Biology and Neuroscience, Fujian Normal University, Fuzhou, Fujian Province, China
  • Online:2020-07-15 Published:2020-09-12
  • Contact: Dong-Mei Wang, PhD, dmwang@fjnu.edu.cn.
  • Supported by:
    This work was supported by the National Natural Science Foundation of China, No. 81400922 (to DMW), 81571084; the Natural
    Science Foundation of Fujian Province of China, No. 2018J01813 (to DMW); the College of Life Sciences of Fujian Normal University of China,
    No. FZSKG2018016 (to DMW).

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Abstract:

Adrenomedullin, a peptide with multiple physiological functions in nervous system injury and disease,
has aroused the interest of researchers. This review summarizes the role of adrenomedullin in neuropatho
logical disorders, including pathological pain, brain injury and nerve regeneration, and their treatment.
As a newly characterized pronociceptive mediator, adrenomedullin has been shown to act as an upstream
factor in the transmission of noxious information for various types of pathological pain including acute
and chronic inflammatory pain, cancer pain, neuropathic pain induced by spinal nerve injury and diabetic
neuropathy. Initiation of glia-neuron signaling networks in the peripheral and central nervous system by
adrenomedullin is involved in the formation and maintenance of morphine tolerance. Adrenomedullin has
been shown to exert a facilitated or neuroprotective effect against brain injury including hemorrhagic or
ischemic stroke and traumatic brain injury. Additionally, adrenomedullin can serve as a regulator to pro
mote nerve regeneration in pathological conditions. Therefore, adrenomedullin is an important participant
in nervous system diseases.

Key words: adrenomedullin, brain injury, glia, mechanism, morphine tolerance, neural regeneration, neuroprotective effect, pathological pain, regeneration, sensitization, target