Neural Regeneration Research ›› 2016, Vol. 11 ›› Issue (1): 94-100.doi: 10.4103/1673-5374.175052

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Neuroprotective effect of Shenqi Fuzheng injection pretreatment in aged rats with cerebral ischemia/reperfusion injury

Ying-min Cai, Yong Zhang, Peng-bo Zhang, Lu-ming Zhen, Xiao-ju Sun, Zhi-ling Wang, Ren-yan Xu, Rong-liang Xue   

  1. Department of Anesthesiology, Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi Province, China
  • Received:2015-10-07 Online:2016-01-15 Published:2016-01-15
  • Contact: Yong Zhang, 15902957876@126.com.
  • Supported by:

    This study was supported by a grant from Key Technology Research and Development Program of Shaanxi Province of China, No. 2003K10-G86; the National Natural Science Foundation of China, No. 30070731.

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Abstract:

Shenqi Fuzheng injection is extracted from the Chinese herbs Radix Astragali and Radix Codonopsis. The aim of the present study was to investigate the neuroprotective effects of Shenqi Fuzheng injection in cerebral ischemia and reperfusion. Aged rats (20–22 months) were divided into three groups: sham, model, and treatment. Shenqi Fuzheng injection or saline (40 mL/kg) was injected into the tail vein daily for 1 week, after which a cerebral ischemia/reperfusion injury model was established. Compared with model rats that received saline, rats in the treatment group had smaller infarct volumes, lower brain water and malondialdehyde content, lower brain Ca2+ levels, lower activities of serum lactate dehydrogenase and creatine kinase, and higher superoxide dismutase activity. In addition, the treatment group showed less damage to the brain tissue ultrastructure and better neurological function. Our findings indicate that Shenqi Fuzheng injection
exerts neuroprotective effects in aged rats with cerebral ischemia/reperfusion injury, and that the underlying mechanism relies on oxygen free radical scavenging and inhibition of brain Ca2+ accumulation.

Key words: nerve regeneration, cerebral ischemia/reperfusion, Shenqi Fuzheng injection, aged rats, neurological function, Ca2+, oxygen free radicals, NSFC grant, neural regeneration