Neural Regeneration Research ›› 2016, Vol. 11 ›› Issue (1): 174-179.doi: 10.4103/1673-5374.175067

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Vascular endothelial growth factor: an attractive target in the treatment of hypoxic/ischemic brain injury

Hui Guo 1, 2, Hui Zhou 1, 2, Jie Lu 3, Yi Qu 1, 2, Dan Yu 1, 2, Yu Tong 1, 2   

  1. 1 Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan Province, China
    2 Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan Province, China
    3 Department of Medical Cosmetology, Chengdu Second People’s Hospital, Chengdu, Sichuan Province, China
  • Received:2015-10-12 Online:2016-01-15 Published:2016-01-15
  • Contact: Yu Tong or Dan Yu,zisu_yu@163.com or yd540@126.com.
  • Supported by:

    This study was supported by the National Natural Science Foundation of China, No. 81401238, 81330016, 31171020, 81172174 and 81270724; the grants from Ministry of Education of China, No. 313037, 20110181130002; a grant from State Commission of Science Technology of China, No. 2012BAI04B04; the grants from Science and Technology Bureau of Sichuan Province of China, No. 2012SZ0010, 2014FZ0113, 2014SZ0149; and a grant from Clinical Discipline Program (Neonatology) from the Ministry of Health of China, No. 1311200003303.

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Abstract:

Cerebral hypoxia or ischemia results in cell death and cerebral edema, as well as other cellular reactions such as angiogenesis and the reestablishment of functional microvasculature to promote recovery from brain injury. Vascular endothelial growth factor is expressed in the central nervous system after hypoxic/ischemic brain injury, and is involved in the process of brain repair via the regulation of angiogenesis, neurogenesis, neurite outgrowth, and cerebral edema, which all require vascular endothelial growth factor signaling. In this review, we focus on the role of the vascular endothelial growth factor signaling pathway in the response to hypoxic/ischemic brain injury, and discuss potential therapeutic interventions.

Key words: nerve regeneration, VEGF, VEGFR, HIF1, PI3K/Akt pathway, Akt/eNOS pathway, JAK/STAT, Src-SSeCKS pathway, hypoxic/ischemic brain injury, neural regeneration