Is type I alpha 2 collagen gene responsible for intracranial aneurysm in Northeast China?

doi:10.3969/j.issn.1673-5374.2013.05.008

Abstract

Abstract:

In this study, we investigated whether a single nucleotide polymorphism (rs42524 G > C) in the type I alpha 2 collagen gene was associated with sporadic ruptured intracranial aneurysm or its clinical characteristics in patients from Northeast China. Genotyping of the rs42524 G > C polymorphism was carried out using a polymerase chain reaction-restriction fragment length polymorphism assay. The data showed that the frequency of the rs42524 GC + CC genotype was significantly higher than the GG genotype among intracranial aneurysm patients whose Hunt and Hess grading scale was > 3. In addition, the rs42524 G > C genotype was found to have a statistically significant association with intracranial aneurysm risk. These findings indicate that the type I alpha 2 collagen gene may be involved in a predisposition to intracranial aneurysm in the Northeast Chinese population. Crucially, the rs42524 C allele may be an important risk factor for increased severity of the condition in patients with ruptured intracranial aneurysms.

Key words: neural regeneration, clinical practice, intracranial aneurysm, type I collagen gene, single nucleotide polymorphism, polymerase chain reaction-restriction fragment length polymorphism assay, susceptibility, risk factors, neuroregeneration

Pengfei Wu, Bo Li, Anhua Wu, Yunjie Wang. Is type I alpha 2 collagen gene responsible for intracranial aneurysm in Northeast China?[J]. Neural Regeneration Research, 2013, 8(5): 445-451.

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