Sericin protects against diabetes-induced injuries in sciatic nerve and related nerve cells

doi:10.3969/j.issn.1673-5374.2013.06.003

Abstract

Abstract:

Sericin from discarded silkworm cocoons of silk reeling has been used in different fields, such as cosmetology, skin care, nutrition, and oncology. The present study established a rat model of type 2 diabetes by consecutive intraperitoneal injections of low-dose (25 mg/kg) streptozotocin. After intragastrical perfusion of sericin for 35 days, blood glucose levels significantly declined, and the expression of neurofilament protein in the sciatic nerve and nerve growth factor in L4–6 spinal ganglion and anterior horn cells significantly increased. However, the expression of neuropeptide Y in spinal ganglion and anterior horn cells significantly decreased in model rats. These findings indicate that sericin protected the sciatic nerve and related nerve cells against injury in a rat type 2 diabetic model by upregulating the expression of neurofilament protein in the sciatic nerve and nerve growth factor in spinal ganglion and anterior horn cells, and downregulating the expression of neuropeptide Y in spinal ganglion and anterior horn cells.

Key words: neural regeneration, traditional Chinese medicine, peripheral nerve injury, diabetes mellitus, sericin, sciatic nerve, spinal ganglion cells, anterior horn cells, nerve cells, neurofilament protein, nerve growth factor, neuropeptide Y, streptozotocin, photographs-containing paper, neuroregeneration

Chengjun Song, Zhenjun Yang, Meirong Zhong, Zhihong Chen. Sericin protects against diabetes-induced injuries in sciatic nerve and related nerve cells[J]. Neural Regeneration Research, 2013, 8(6): 506-513.

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