Neural Regeneration Research ›› 2017, Vol. 12 ›› Issue (1): 90-95.doi: 10.4103/1673-5374.198990

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Breviscapine reduces neuronal injury caused by traumatic brain injury insult: partly associated with suppression of interleukin-6 expression

 Ling Jiang, Yue Hu, Xiang He, Qiang Lv, Ting-hua Wang, Qing-jie Xia   

  1. Institute of Neurological Disease, Department of Anesthesiology and Translation Neuroscience Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China
  • Received:2016-11-26 Online:2017-01-15 Published:2017-01-15
  • Contact: Qing-jie Xia, Ph.D., xiaqj2005@126.com.

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Abstract:

Breviscapine, extracted from the herb Erigeron breviscapus is widely used for the treatment of cardiovascular diseases, cerebral infarct, and stroke, but its mechanism of action remains unclear. This study established a rat model of traumatic brain injury induced by controlled cortical impact, and injected 75 μg breviscapine via the right lateral ventricle. We found that breviscapine significantly improved neurobehavioral dysfunction at 6 and 9 days after injection. Meanwhile, interleukin-6 expression was markedly down-regulated following breviscapine treatment.Our results suggest that breviscapine is effective in promoting neurological behavior after traumatic brain injury and the underlying molecular mechanism may be associated with the suppression of IL-6.

Key words: nerve regeneration, breviscapine, traumatic brain injury, neuroprotective effect, interleukin-6, neural regeneration