Neural Regeneration Research ›› 2018, Vol. 13 ›› Issue (1): 67-68.doi: 10.4103/1673-5374.224372

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Astrocytes in the cerebral cortex play a role in the spontaneous motor recovery following experimental striatal hemorrhage

 Juliana Dalibor Neves1, 2,  Régis Gemerasca Mestriner3, Carlos Alexandre Netto1, 2   

  1. 1 Graduate Program of Physiology, Institute of Basic Health Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil;
    2 Department of Biochemistry, Institute of Basic Health Science, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil;
    3 Neurorehabilitation and Neural Repair Research Group, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil
  • Received:2017-12-15 Online:2018-01-15 Published:2018-01-15
  • Contact: Juliana Dalibor Neves, Ph.D.,julianadn@gmail.com.

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Abstract:

Intracerebral hemorrhage (ICH) is a stroke subtype caused by spontaneous rupture of small vessels and bleeding into the brain parenchyma,resulting in cell death and sensorimotor deficits. Despite the greater prevalence of the ischemic form of stroke (87%), ICH has the highest mortality rate of all stroke subtypes. The striatum is the most affected structure in hemorrhagic stroke (35–70%), followed by cerebral cortex (15–30%), brain stem and cerebellum (5–10%); patients suffering striatal and/or cortical ICH bear persistent sensorimotor disabilities. Although chronic sensorimotor impairment is established,a considerable amount of patients experience some degree of spontaneous recovery during the first six months after stroke (Qureshi et al., 2009), and the neurobiological basis of this process is not understood.