Neural Regeneration Research ›› 2026, Vol. 21 ›› Issue (1): 318-319.doi: 10.4103/NRR.NRR-D-24-01115

Previous Articles     Next Articles

P2X7 receptors and multiple sclerosis: A potential biomarker and therapeutic target?

Cristina Agliardi, Franca Rosa Guerini* , Mario Clerici   

  1. IRCCS Fondazione Don Carlo Gnocchi ONLUS, Milan, Italy (Agliardi C, Guerini FR, Clerici M) Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy (Clerici M)
  • Online:2026-01-15 Published:2025-04-23
  • Contact: Franca Rosa Guerini, PhD, fguerini@dongnocchi.it.
  • Supported by:
    This work was supported by Italian Ministry of Health Ricerca Corrente [RC 2023] and RF-2016-02361294, also supported by #NEXTGENERATIONEU (NGEU) and funded by the Ministry of University and Research (MUR), National Recovery and Resilience Plan (NRRP), project MNESYS (PE0000006) – A Multiscale integrated approach to the study of the nervous system in health and disease (DN. 1553 11.10.2022) (to FRG). The work was also partially supported by a grant from Fondazione Romeo ed Enrica Invernizzi (to FRG).

Abstract: Multiple sclerosis (MS) is a chronic, autoimmune and neuroinflammatory disease of the central nervous system (CNS) with a neurodegenerative component, characterized by demyelination and degeneration of nerve fibers. It affects mainly young adults (aged 20 to 45 years) and its causes are still unknown, but it is thought that external factors such as viruses and environmental factors trigger the disease in people with a genetic susceptibility. Patients are classified into four main categories based on the clinical course of the disease: relapsing remitting (RR)-MS, the most common form, characterized by relapses and periods of remission; secondary progressive (SP)-MS, which may develop secondarily in RR-MS patients, characterized by continuous worsening with or without periods of remission; primary progressive (PP)-MS in which symptoms continue to worsen from the onset of the disease. In particular, the PP-MS form is more resistant to the currently available pharmacological treatments used to treat the other forms, and progressive relapsing-MS, a rare form characterized by continuous disease progression from the onset.