Neural Regeneration Research ›› 2026, Vol. 21 ›› Issue (1): 320-321.doi: 10.4103/NRR.NRR-D-24-01156

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Alpha-synuclein-induced upregulation of SKI family transcriptional corepressor 1: A new player in aging and Parkinson’s disease?

Lauren Barrett# , Rebekah Bevans# , Aideen M. Sullivan, Louise M. Collins, Gerard W. O’Keeffe*   

  1. Department of Anatomy and Neuroscience, School of Medicine, University College Cork, Cork, Ireland (Barrett L, Bevans R, Collins LM, O’Keeffe GW) Department of Pharmacology and Therapeutics, School of Medicine, University College Cork, Cork, Ireland (Sullivan AM)
  • Online:2026-01-15 Published:2025-04-23
  • Contact: Gerard W. O’Keeffe, PhD, g.okeeffe@ucc.ie.
  • Supported by:
    Work in the authors’ laboratories was supported by Science Foundation Ireland (Grant 19/FFP/6666), Cure Parkinson’s (Grant CP: GO01), and a PhD studentship from the Anatomical Society.

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Abstract: SKI family transcriptional corepressor 1 (SKOR1; also known as LbxCor1, Fussel15, or CORL1), is a member of the SKI family of proteins and is transcribed from a protein-coding gene located on chromosome 15 in humans, that has a molecular weight of approximately 100 kDa. Skor1 is highly expressed in neurons in the central nervous system of both humans and rodents. It has been shown to regulate the transcription of genes that are involved in pathways related to restless legs syndrome (RLS) (Sarayloo et al., 2020), and SKOR1 genetic variants have been associated with RLS (Jimenez-Jimenez et al., 2018). RLS is a common neurological condition that has a strong genetic component, with many cases being linked to hereditary factors; RLS often occurs secondary to other medical conditions including neuropathies such as Parkinson’s disease (PD) (Ondo et al., 2002).