Neural Regeneration Research ›› 2026, Vol. 21 ›› Issue (9): 4255-4256.doi: 10.4103/NRR.NRR-D-25-01128
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Dheyaa Al-Sallami*, Shelley Tischkau, Raheem F. H. Al Aameri, Leonard P. Rybak
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Abstract: The emerging connection: As populations age, the link between age-related hearing loss (ARHL) and Alzheimer’s disease (AD) is emerging as one of the most urgent public health challenges of our time. Recent research analyzing 2946 communitydwelling adults revealed that hearing loss may contribute to nearly one-third of all new dementia cases — significantly higher than previous estimates. This epidemiological evidence suggests a mechanistic rather than coincidental relationship. Longitudinal studies show hearing loss precedes cognitive decline by 5–10 years. The implications are demographically profound. The yearly costs related to dementia are over $1.3 trillion, and untreated hearing loss adds another $133 billion in lost productivity. As a result, it has become essential to clarify the mechanistic link between these disorders. ARHL affects approximately one-third of adults over 65 years and rises to 75% in those over 80 years.In contrast, AD remains the leading cause of dementia, accounting for 60%–80% of all cases.
Dheyaa Al-Sallami, Shelley Tischkau, Raheem F. H. Al Aameri, Leonard P. Rybak. Cochlear amyloid beta 42–mediated hearing loss: A marker of preclinical Alzheimer’s disease#br# #br# #br#[J]. Neural Regeneration Research, 2026, 21(9): 4255-4256.
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URL: https://www.sjzsyj.com.cn/EN/10.4103/NRR.NRR-D-25-01128
https://www.sjzsyj.com.cn/EN/Y2026/V21/I9/4255