Neural Regeneration Research ›› 2026, Vol. 21 ›› Issue (9): 4257-4258.doi: 10.4103/NRR.NRR-D-25-01192

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Alpha-synuclein structural variantsdriving tau pathology and disease interaction

Chuanqi Sun*   

  1. Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA, USA
    Departments of Biological Chemistry and Chemistry and Biochemistry, UCLA-DOE Institute, UCLA, CA, USA

  • Online:2026-09-15 Published:2026-05-14
  • Contact: Chuanqi Sun, PhD, sunchuanqi@g.ucla.edu.

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Abstract: Redefining neurodegenerative diseases: from isolated protein pathologies to intertwined disease networks: A common feature of neurodegenerative diseases such as Parkinson’s disease (PD), Alzheimer’s disease (AD), Lewy body dementia, and multiple system atrophy is the accumulation of misfolded, insoluble protein aggregates in specific neurons or glial cells. In AD, these aggregates are mainly manifested as neurofibrillary tangles composed of Tau protein, while in PD, they are mainly manifested as Lewy bodies composed of α-synuclein.