Neural Regeneration Research ›› 2012, Vol. 7 ›› Issue (15): 1179-1184.

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Effect of chitosan/type I collagen/gelatin composites in biocompatibility and nerve repair

Qing Wang1, Xiaolei Yang2, Ming Ren2, Yulin Hu3, Qiang Chen2, Lei Xing2, Chunyang Meng2, Tiemei Liu1   

  1. 1 China-Japan Union Hospital, Jilin University, Changchun 130033, Jilin Province, China
    2 Department of Toxicology, School of Public Health, Jilin University, Changchun 130021, Jilin Province, China
    3 Department of Liver, Gall and Pancreas, First Hospital of Jilin University, Changchun 130021, Jilin Province, China
  • Received:2012-02-03 Revised:2012-04-24 Online:2012-05-25 Published:2012-05-25
  • Contact: Tiemei Liu, M.D., Professor, China-Japan Union Hospital, Jilin University, Changchun 130033, Jilin Province, China liutiemei777@163.com
  • About author:Qing Wang☆, M.D., Professor, China-Japan Union Hospital, Jilin University, Changchun 130033, Jilin Province, China

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Abstract:

Chitosan, collagen I and gelatin were mixed in appropriate quantities to develop a new nerve repair material, with good arrangement and structure, as well as even aperture size. The composite material was sterilized by 60Co irradiation for 24 hours prior to implantation in the right thigh of rats following sciatic nerve damage. Results showed that the material was nontoxic to the kidneys and the liver, and did not induce an inflammatory response in the muscles. The composite material enhanced the recovery of sciatic nerve damage in rats. These experimental findings indicate that the composite material offers good biocompatibility and has a positive effect on injured nerve rehabilitation.

Key words: chitosan, collagen I, gelatin, biomaterials, biocompatibility, nerve repair, neural regeneration