Neural Regeneration Research ›› 2021, Vol. 16 ›› Issue (9): 1801-1802.doi: 10.4103/1673-5374.306084

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Microglial exosomes in retinal neuroinflammation: focus in glaucoma

Inês Dinis Aires, Ana Raquel Santiago*   

  1. University of Coimbra, Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, Coimbra, Portugal (Aires ID, 
    Santiago AR)
    University of Coimbra, Center for Innovative Biomedicine and Biotechnology (CIBB), Coimbra, Portugal (Aires ID, Santiago AR)
     Clinical Academic Center of Coimbra (CACC), Coimbra, Portugal (Aires ID, Santiago AR)
    Association for Innovation and Biomedical Research on Light and Image (AIBILI), Coimbra, Portugal (Santiago AR)
  • Online:2021-09-15 Published:2021-02-05
  • Contact: Ana Raquel Santiago, PhD, asantiago@fmed.uc.pt.
  • Supported by:
    This work was supported by the Foundation for Science and Technology (FCT), Portugal (Strategic Projects UID/NEU/04539/2013, UID/NEU/04539/2019, UIDB/04539/2020 and UIDP/01/2020); PhD fellowships (PD/BD/52294/2013, PD/BD/114115/2015 and PD/BD/127821/2016); COMPETE-FEDER (FCOMP-01-0124-FEDER-028417 and POCI-01-0145-FEDER-007440); Centro 2020 Regional Operational Programme (CENTRO-01-0145-FEDER-000008: BRAINHEALTH 2020); Banco Santander Totta (grant FMUC-BST-2016-224).  

Abstract: Glaucoma is a leading cause of irreversible blindness, expected to affect 140 million people worldwide by the year 2040. The pathophysiology of glaucoma involves retinal ganglion cell loss, optic nerve atrophy and cupping of the optic disk, culminating in visual field loss (Boia et al., 2020). Glaucoma is a multifactorial disease in which increased intraocular pressure is the main risk factor. Therefore, the majority of experimental models are based on ocular hypertension that mimics in some extend the features of clinical glaucoma (Aires et al., 2017). Elevated hydrostatic pressure is also suitable to disentangle the cellular mechanisms involved in disease progression, using cultured cells or tissues (Aires et al., 2017).