Neural Regeneration Research ›› 2022, Vol. 17 ›› Issue (2): 304-306.doi: 10.4103/1673-5374.317965

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Stressed axons craving for glial sugar: links to regeneration?

Elisabetta Babetto, Bogdan Beirowski*   

  1. Hunter James Kelly Research Institute, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA (Babetto E, Beirowski B)
    Department of Biochemistry, Jacobs School of Medicine and Biomedical Sciences,
    University at Buffalo, Buffalo, NY, USA (Beirowski B)
    Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA (Babetto E) 
  • Online:2022-02-15 Published:2021-10-08
  • Contact: Bogdan Beirowski, MD, PhD, bogdanbe@buffalo.edu.
  • Supported by:
    This current work was supported by grants from the National Institute of Health (R01NS111024) and the Muscular Dystrophy Association (577844) as well as Start-Up Funding provided through the Empire State Development Corporation for Hunter James Kelly Research Institute grant nos. W753 and U446 and the Hunter’s Hope Foundation (to BB). 

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Abstract: The contrary but interrelated processes of axon degeneration and regeneration are the yin and yang of many neurodegenerative conditions. Here we discuss recent evidence for metabolic cross-talk between glia and injured axons regulating these processes. We especially focus on potential bioenergetic mechanisms as to how axon-flanking glia may promote regeneration.