Neural Regeneration Research ›› 2022, Vol. 17 ›› Issue (2): 307-308.doi: 10.4103/1673-5374.317966

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Contribution of adult-born neurons to memory consolidation during rapid eye movement sleep

Akinobu Ohba, Masanori Sakaguchi*   

  1. International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Ibaraki, Japan
  • Online:2022-02-15 Published:2021-10-08
  • Contact: Masanori Sakaguchi, MD, PhD, masanori.sakaguchi@gmail.com.
  • Supported by:
    This work was partially supported by grants from the World Premier International Research Center Initiative from MEXT, JST CREST grant #JPMJCR1655, JSPS KAKENHI grants #16K18359, 15F15408, 15H01276, 15K18332, 26115502, 25116530, JP16H06280, and 20H03552, Takeda Science Foundation, Shimadzu Science Foundation, Kanae Foundation, Research Foundation for Opto-Science and Technology, Ichiro Kanehara Foundation, Kato Memorial Bioscience Foundation, Japan Foundation for Applied Enzymology, Senshin Medical Research Foundation, Life Science Foundation of Japan, Uehara Memorial Foundation, Brain Science Foundation, Kowa Life Science Foundation, Inamori Research Grants Program, and GSK Japan to MS. 

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Abstract: Introduction: Memory consolidation stabilizes newly acquired memories by integrating them into pre-existing memory networks, which is thought to occur via changes in synaptic strength. Sleep may influence memory consolidation by modifying synaptic strength through local neuronal oscillatory activity. Recently, we found that the activity of hippocampal adult-born neurons (ABNs) is critical for memory consolidation during sleep (Kumar et al., 2020). Here, we propose a hypothesis for how changes in ABN synaptic plasticity synchronized with neural oscillations may contribute to memory consolidation during sleep.