Neural Regeneration Research ›› 2012, Vol. 7 ›› Issue (4): 302-307.

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Nerve growth factor and inducible nitric oxide synthase expression in the mesencephalon and diencephalon, as well as visual- and auditory-related nervous tissues, in a macaque model of type 2 diabetes

Qihui Luo1, 2, 3, Wentao Liu1, 2, Jingyao Chen1, 2, Mingshu Wang1, 2, 3, Wen Zeng2, 4, Zhengli Chen1, 2, 3, Anchun Cheng1, 2, 3   

  1. 1  College of Veterinary Medicine, Sichuan Agricultural University/Key Laboratory of Animal Disease and Human Health of Sichuan Province, Ya’ an 625014, Sichuan Province, China
    2  Experimental Animal Engineering Center, Sichuan Agricultural University/Provenance Source De pot of Macaque for National Experiment, Ya’ an 625014, Sichuan Province, China
    3  Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan Province, China
    4  Sinopharm Center for Safety Evaluation and Research, Chengdu 610051, Sichuan Province, China
  • Received:2011-09-24 Revised:2011-12-22 Online:2012-02-05 Published:2012-02-05
  • Contact: Zhengli Chen (Doctor, Associate professor) and Anchun Cheng, College of Veterinary Medicine, Sichuan Agricultural University/Key Laboratory of Animal Disease and Human Health of Sichuan Province, Ya’ an 625014, Sichuan Province, China; Experimental Animal Engineering Center, Sichuan Agricultural University/Provenance Source De pot of Macaque for National Experiment, Ya’ an 625014, Sichuan Province, China; Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan Province, China chzhli75@163.com; chenganchun@vip.163.com
  • About author:Qihui Luo☆, Studying for doctorate, College of Veterinary Medicine, Sichuan Agricultural University/Key Laboratory of Animal Disease and Human Health of Sichuan Province, Ya’ an 625014, Sichuan Province, China; Experimental Animal Engineering Center, Sichuan Agricultural University/Provenance Source De Pot of Macaque for National Experiment, Ya’ an 625014, Sichuan Province, China; Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan Province, China Qihui Luo, Wentao Liu and Jingyao Chen contribute equally to this work.

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Abstract:

The present study detected distribution and expression of nerve growth factor and inducible nitric oxide synthase in the mesencephalon and diencephalon, as well as visual- and auditory-related nervous tissues, in a macaque model of type 2 diabetes using immunohistochemistry. Results showed that nerve growth factor expression decreased, but inducible nitric oxide synthase expression increased, in the mesencephalon and diencephalon, as well as visual- and auditory- related nervous tissues. These results suggested that nerve growth factor and inducible nitric oxide synthase play an important role in regulating the development of diabetic visual- and auditory-related diseases.

Key words: diencephalon, immunohistochemistry, inducible nitric oxide synthase, mesencephalon, nerve growth factor, neural regeneration, optic nerve, type 2 diabetes