Neural Regeneration Research ›› 2012, Vol. 7 ›› Issue (2): 146-151.

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Tissue plasminogen activator-independent roles of neuroserpin in the central nervous system

Jiao Ma1, 2, 3, Yu Tong1, 2, 3, Dan Yu1, 2, 3, Meng Mao1, 2, 3
  

  1. 1 Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
    2 Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
    3 Laboratory of Early Developmental and Injuries, West China Institutes for Woman and Children’s Health, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
  • Received:2011-09-18 Revised:2011-11-19 Online:2012-01-15 Published:2012-01-15
  • Contact: Meng Mao, M.D., Professor, De-partment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China; Key Labor-atory of Obstetric & Gyneco-logic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China; Laboratory of Early Developmental and Injuries, West China Institutes for Woman and Children’s Health, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China;
  • About author:Jiao Ma★, Master, Depart-ment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China; Key Labor-atory of Obstetric & Gyneco-logic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China; Laboratory of Early Developmental and Injuries, West China Institutes for Woman and Children’s Health, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China

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Abstract:

A number of studies have confirmed the existence of tissue-type plasminogen activator-independent roles of neuroserpin, a member of the serine protease inhibitor superfamily. In this review article, we aim to clarify this role. These unique roles of neuroserpin are involved in its neuroprotective effect during ischemic brain injury, its regulation of tumorigenesis, and the mediation of emotion and cognition through the inhibition of urokinase-type plasminogen activator and fibrinolysin, modification of Th cells, reducing plaque formation, promoting process growth and intracellular adhesion, and altering the expression of cadherin and nuclear factor kappa B.

Key words: neuroserpin, tissue-type plasminogen activator, serpin, cerebral ischemia, tumor, familial encephalopathy with neuroserpin inclusion bodies