Neural Regeneration Research ›› 2012, Vol. 7 ›› Issue (2): 141-145.

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The role of autophagy in Parkinson’s disease

Lei Zhang1, Yaru Dong2, Xiaoheng Xu1, Zhong Xu1   

  1. 1  Department of Pediatrics, the Second Hospital of Jilin University, Changchun 130041, Jilin Province, China
    2  Department of Ophthalmology, the Second Hospital of Jilin University, Changchun 130041, Jilin Province, China
  • Received:2011-10-20 Revised:2011-12-05 Online:2012-01-15 Published:2012-01-15
  • Contact: Lei Zhang, Department of Pe-diatrics, the Second Hospital of Jilin University, Changchun 130041, Jilin Province, China zhang_lei@jlu.edu.cn
  • About author:Lei Zhang☆, Doctor, Attend-ing physician, Department of Pediatrics, the Second Hospital of Jilin University, Changchun 130041, Jilin Province, China

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Abstract:

Although Parkinson’s disease is the most common neurodegenerative movement disorder, the mechanisms of pathogenesis remain poorly understood. Recent findings have shown that deregulation of the autophagy-lysosome pathway is involved in the pathogenesis of Parkinson’s disease. This review summarizes the most recent findings and discusses the unique role of the autophagy-lysosome pathway in Parkinson’s disease to highlight the possibility of Parkinson’s disease treatment strategies that incorporate autophagy-lysosome pathway modulation.

Key words: autophagy-lysosome pathway, Parkinson’s disease, pathogenesis, review